Current Issue : July-September Volume : 2013 Issue Number : 3 Articles : 12 Articles
Traditionally, Tecomaria capensis used as medicine to relieve pain, slepplessness, diarrhea and in flammation. In my previous study methanolic extract of Tecomaria capensis leaves (TCLE) showed good antimicrobial, analgesic, anti-inflammatory, antipyretic, wound healing, antidiabetic and antidiarrheal activity. For the safer use of this plant extract in further research need to evaluate toxicity. So’ this study designed to evaluate acute toxicity considering different parameters and higher dose (500 mg/kg). Five group (n=6) of albino rats treated with single dose of distilled water, TCLE 300 mg/kg, 1000 mg/kg, 3000 mg/kg and 5000 mg/kg p.o. respectively, and kept under observation (Alertness, grooming, touch response, convulsions, tremors, excitability, pupil size, food intake, urination, hyperactivity, lacrimation and writhing) up to 14 days. On the 15th day blood were collected and AST, ALT, LDH, urea, glucose, cholesterol and creatinine level determined. In acute toxicity study, the extract administration up to a higher dose 5000 mg/kg body weight did not cause any mortility, and toxic change in behavior and biochemical parameters of the animals. Methanolic extract of Tecomaria capensis leaves safe and nontoxic up to 5000 mg/kg p.o. Our study may be useful to use safer dose of this plant extract in further research....
The present work carried out for emergence of antibiotic resistant bacterial strains and the gastro-intestinal helminthes are growing problems and are an important concern for patients, physicians, healthcare managers and policymakers as it results in poorer health and economic outcomes. Results of the antibacterial screening of aqueous and methanolic extracts of pericarp of the fruits of Sapindus trifoliatus revealed that more significant antibacterial activity possessed by aqueous extract than the methanolic extract against almost all the tested bacterial strains. Both the extracts showed paralysis of worms in a time nearer to that of Piperazine citrate, while showed death of worms in a less time compared to Piperazine citrate especially at higher concentration of 80 mg/ml. Antihelmintics and antibacterial agents derived from natural sources possess lesser side effects than synthetic drugs because of biological origin of natural source. This has led to an urgent global call for new antimicrobial drugs, particularly from natural resources....
Traditional Medicines derived from medicinal plants are used by about 60% of the world’s population. A medicinal plant traditionally used in tropical regions. The pharmacological activities of Mangifera include antioxidant, radio protective, antitumor, immunomodulatory, anti-allergic, anti-inflammatory, ant diabetic, lipolytic, antibone resorption, monoamine oxidase inhibiting, antiviral, antifungal antibacterial and ant parasitic properties, which may support the numerous traditional uses of the plant. In the present review focused on the antioxidant activity and total phenolic content and total flavonoids content activity of Mangnifera Indica from fruit powder and leaf. Mangnifera Indica peels as an excellent source of bioactive compounds and the potential of fruit by-product to be utilized as functional food ingredients and nutraceutical products....
Fenugreek (Trigonella foenum-graecum L.) seeds a popular Indian medicinal plant has been commonly used in ayurvedic system of medicine. The plant has been found to possess diverse number of antioxidant activities. It has been commonly used as a traditional food and medicine. This review gives view mainly on the biological activities of some of the fenugreek isolated compounds such as pharmacological actions of the fenugreek extracts, clinical studies and genetic. A study in India involving insulin-dependent diabetics on low doses of insulin, pulverized fenugreek seeds were shown to reduce blood sugar and other harmful fats. This plant has an antioxidant, antibacterial and anticancer activity and use for blood lipids and sugar decreasing in diabetic and non diabetic peoples....
Experimental studies were conducted to evaluate the ameliorating effects of propanolic extract of Trigonella foenum graecum (Fenugreek) seeds in ovarian hormone deficiency induced hyperlipidemia in comparision with atorvastatin. Thirty female wistar rats were divided into five groups i.e., group I – normal control (sham operated), group II – ovariectomized rats (OVX), group III – OVX+Fenugreek extract (1 g/kg b.wt), group IV – OVX+Fenugreek (4 g/kg b.wt) and OVX+Atorvastatin (1.2 mg/kg b.wt p.o.). Body weights were taken at weekly interval. Blood was collected from 8 h fasted animals for the estimation of serum biochemical profile (Lipid profile). There was a significant (p<0.05) increase in the serum total cholesterol and non-HDL cholesterol in group II than other groups. Serum HDL concentrations significantly (p<0.05) increased in groups III, IV and V w.r.t group II. There was a significant (p<0.05) increase in the uterine weights in groups III and IV compared to group II and group V. The liver lipid profile revealed significant (p<0.05) decrease in total lipids, total cholesterol and phospholipids in groups III and IV compared to group II. Liver Triglyceride levels in the liver significantly (p<0.05) increased in group I than group II where as there was no much significant difference among other groups....
Passiflora edulis (Family: Passifloraceae) is commonly known as yellow passion fruit. Previous studies have reported that P. edulis has anti-inflammatory, anti anxiety, antihypertensive, cholesterol and lipid lowering, antioxidant, anti-tumour and antifungal activity. The present study was designed to evaluate analgesic activity of n-butanol extract of Passiflora edulis var. flavicarpa leaves (BEPEL) and fruit peels (BEPEFP) in animal models using tail immersion test, formalin test and eye wipe test. In tail immersion test, BEPEL at a dose of 150 mg/kg and 300 mg/kg, i.p. has shown significant increase in reaction time at 60, 90 and 120 min. intervals (P <0.001). In formalin test, BEPEL in the doses of 150 and 300 mg/ kg, i.p. significantly suppressed both early as well as late phases of pain. In eye wipe test, BEPEL in the dose of 150 and 300 mg/ kg, i.p. significantly reduced number of eye wipe compared to control group. Thus, the result of present investigation confirms the analgesic activity of BEPEL. However BEPEFP did not show any significant effect on pain in the three models used which indicates that BEPEFP is devoid of analgesic activity....
In present study different extracts of Tiliacora acuminata were evaluated for their Anti-inflammatory activity. Hydro-alcoholic, Methanolic, Ethyl acetate and Hexane extracts at 200, 400 and 800mg/kg doses were tested for anti-inflammatory activity using carrageenan induced rat paw oedema model and paw thickness was measured every one hour up to 6 hrs. In Carrageenan induced inflammation model, methanolic extract of T. acuminata aerial parts at three different doses produced significant (P<0.001) reduction when compared to hydroalcoholic, hexane and ethyl acetate extracts. The results obtained suggest marked Anti-inflammatory activity of T. acuminata extracts and supports the traditional use of this plant in some pain full and inflammatory conditions....
The antioxidant potential of polyherbal compounds namely, nephtone was assessed for therapeutic management of an experimental model of oxidative stress induced by ochratoxin, at a toxic level of 2.5 ppm in feed. A total of seventy five sexed male broiler chicks (Cobb strain) of day old age were procured for the study. The chicks were randomly divided into five groups consisting of fifteen in each group. Group 1 received normal basal diet from day 1 to 42nd day. Group 2 received nephtone @ 1.2 ml/15 birds for 1–2 weeks, 2.4 ml/15 birds for 3–4 weeks and 4.8 ml/15 birds for 5–6 weeks. Group 3 was given Ochratoxin @ 2.5 ppm in feed for 42 days. Group 4 was given Ochratoxin @ 2.5 ppm for first 28 days followed by basal diet from 29–42 days. Group 5 birds received combination of ocharatoxin @ 2.5 ppm and nephtone @ 1.2 ml/15 birds for 1–2 weeks, 2.4 ml/15 birds for 42 days from day 1. Antioxidant defense profile (GSH-Px, GSH-R, catalase) was evaluated in blood and GSH, and TBARS was evaluated in liver. Serum parameters like ALT, BUN and total protein were evaluated as biomarkers of hepatic damage and kidney damage. Antioxidant enzyme levels and biochemical parameters were significantly altered in the ochratoxin toxic control groups. These parameters were normal in the controls (groups 1 and 2 and group 5 that was given nephtone therapeutically....
Anticholinergic activity of selected indigenous medicinal plants on sheep tracheal smooth muscle by organ bath studies was carried out. The anticholinergic activity of plant extracts was determined in-vitro by using organ bath in which sheep tracheal smooth muscle was mounted in Krebs-Henseleit solution and its contractile activity for acetylcholine, a known cholinergic spasmogen was recorded in the presence and absence of plant extracts to determine the anticholinergic potential of the extracts of indigenous plants. The percentile contractile response of acetylcholine in the presence and absence of tested plant extracts was recorded. Among the seven indigenous plants tested, acetone extracts of Amaranthus tricolor (leaf), Calotropis gigantean (leaf) and Sesbania grandiflora (leaf) revealed considerable anticholinergic property. The anticholinergic property of these extracts may be helpful in treatment of upper respiratory tract problems and bronchial asthma....
The aim of the study was to investigate the effect of polyherbal compound nephtone on performance indices and serum biochemistry of broiler chickens induced with ochratoxin at a toxic level of 2.5 ppm in feed. A total of seventy five sexed male broiler chicks (Cobb strain) of day old age were procured for the study. The chicks were randomly divided into five groups consisting of fifteen in each group. Group 1 received normal basal diet from day 1 to 42nd day. Group 2 received nephtone @ 1.2 ml/15 birds for 1 – 2 weeks, 2.4 ml /15 birds for 3–4 weeks and 4.8 ml /15 birds for 5–6 weeks. Group 3 was given Ochratoxin @ 2.5 ppm in feed for 42 days. Group 4 was given ochratoxin @ 2.5 ppm for first 28 days followed by basal diet from 29 – 42 days. Group 5 birds received combination of ocharatoxin @ 2.5 ppm and nephtone @ 1.2 ml/15 birds for 1–2 weeks, 2.4 ml/15 birds for 42 days from day 1. Performance parameters such as body weight, feed consumption, body weight gain and feed convertion ratio (FCR) were evaluated. The Serum lipid profile such as Total cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL) and Triglycerides (TG) were also assessed. Performance parameters and lipid profile were significantly altered in the ochratoxin toxic control groups. These parameters were normal in the controls (groups 1 and 2 and group 5 that was given nephtone therapeutically....
The present study was undertaken with a view to validate the traditional use of Boerhaavia diffusa root and Silybum marianum seeds in combination as a hepatoprotective agent against non alcoholic fatty liver disease. The alcoholic extracts of Boerhaavia diffusa roots (150 mg / kg, p. o.) and Silybum marianum (150 mg / kg, p. o.) seeds were administered to the experimental rats individually, and in combination (75 mg / kg + 75 mg /kg), p. o. by dispersing it in 1% Tween 80, were given, of different groups respectively. After intoxication with High fructose diet (HFD) fructose solution to the animals orally for six weeks serum levels of various enzymes were recorded. Serum levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin, total protein and cholesterol level were assessed. Boerhaavia diffusa roots and Silybum marianum seeds extracts and silymarin exhibited a significant hepatoprotective effect as evident from the decreases of serum AST, ALT, ALP, TB and cholesterol and increases in levels of TP compared with control group (P<0.01 or P<0.05). The effect of combination of both the extract exerts more hepatoprotective as revealed by more level of significance. The present finding suggests that the hepatoprotective effect of Boerhaavia diffusa roots and Silybum marianum seeds extract....
A total of 60 sexed male broiler chicks of Vencobb strain of day-old age were randomly divided into six groups consisting of fifteen chicks in each group. Group 1 was maintained as basal diet control and group 2 on lead @ 300 ppm in feed throughout 5 wks as toxic control without any treatment. Group 3 was maintained on Herbal Methionine @ 25% above normal level in feed (1.4 gm/ kg feed) and Group 4 was treated with lead + Herbal Methionine for the 5 wks (35 days).The lead toxic control group showed a significant (P<0.05) reduction in body weight, body weight gain where as the treatment with herbal Methionine resulted in a marked improvement in all the above parameters. Feed conversion ratio was also improved in treatment group but increase is not significant....
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